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The reversibility of these deleterious sequelae by SAMe supplementation in animal models of AD warrants further exploration in humans, where similar results could revolutionize the treatment of AD

Longer sessions require more clinician time and monitoring

How long it takes for specific symptoms to dissipate will depend on what exactly is causing those symptoms

Because of the substantial amounts of brain glutathione and its rapid turnover under homeostatic control, we hypothesized that glutathione is a relevant reservoir of glutamate, and could influence synaptic excitability

In general, excess ROS causes the production of a few enzymes, such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, xanthine oxidase (XO), lipoxygenase (LO), cytochrome P450 (CYP450), myeloperoxidase (MPO), iron (Fe), and copper (Cu) proteins