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Systemic Effects: Do biological effects of oral BPC-157 result from absorbed peptide acting systemically, or from local effects on gastrointestinal tissues before absorption

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Following subcutaneous injection, the peptide enters systemic circulation with bioavailability of 14-19% in rats, while intramuscular administration achieves 45-51% bioavailability in beagle dogs, indicating both route-dependent and species-dependent absorption characteristics

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Confounding Variable A factor that is related to both the treatment and the outcome, which can distort the apparent effect if not accounted for