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TB-500 has been characterised as having significant anti-inflammatory properties with studies examining how TB-500 influences macrophage behaviour, inflammatory cytokine production, neutrophil activity at injury sites, and the transition from pro-inflammatory to anti-inflammatory and pro-repair phases of the tissue healing response

Kynurenine production insufficiency theory Recent research has identified the aryl hydrocarbon receptor (AhR) and the enzyme indoleamine-2,3-dioxygenase (IDO) as key players in the increased gut permeability and bacterial endotoxin translocation seen in ME/CFS patients

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