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However, adjustments may be considered if: Glycaemic targets are not achieved : Your doctor may increase to the next available dose strength Intolerable side effects persist : A temporary dose reduction or slower titration may be appropriate Weight loss plateaus (for weight management indications): Dose optimisation may be discussed Renal function changes : Monitoring may be increased, though most GLP-1s don't require dose adjustment Other medications are added or removed : Particularly other glucose-lowering agents Important considerations during dose changes: Never skip doses or double up if you miss an injectionfollow the specific guidance in your patient information leaflet For missed doses, each product has different instructions: Semaglutide (Ozempic/Wegovy): If within 5 days, take as soon as possible

PMID 20190676 TB-4 biodistribution - Urinary clearance and rapid blood-level decline after injection

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[DOI] [PMC free article] [PubMed] [Google Scholar] 19.Price J.A., Sanny C.G., Shevlin D