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For instance, in addition to inactivate the incretin hormones, DPP4 can also affect the orexigenic hormone neuropeptide Y, and its inhibition by gliptines enhances antilipolytic action in human adipose tissue leading to further accumulation of body fat [144, 145]

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The EMA's Pharmacovigilance Risk Assessment Committee (PRAC) conducted a comprehensive safety review in 20232024 examining reports of suicidal and self-injurious thoughts with GLP-1 receptor agonists used for both diabetes and weight management