They are not indicated for type 1 diabetes, should not be used with DPP-4 inhibitors, and require caution in patients with pancreatitis history or diabetic retinopathy
Liang XH, Kleeman LK, Jiang HH, Gordon G, Goldman JE, Berry G, et al
pharmaceutical industry, drug approval for certain indications requires a rigorous process that relies heavily on research evidence from preclinical studies and clinical trials
It is important to note that these medications are not intended for cosmetic weight loss or for individuals looking to lose a small amount of vanity weight. They are powerful metabolic tools designed for those whose weight is significantly impacting their long-term health and quality of life
Notably, lactate does not usually accumulate in the healthy gut because microbes can convert it further to propionate, butyrate, or acetate ( Table 1 Metabolites induced by inulin fermentation