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Many compounds that looked effective in animals later failed human trials or revealed safety concerns

Background and isolation BPC-157 is a synthetic 15-amino-acid peptide with the sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (GEPPPGKPADDAGLV) and a monoisotopic molecular weight of approximately 1419.55 Da (Sikiric et al., 2018)

Research-grade BPC-157 should have purity above 98% verified by HPLC or mass spectrometry

8 Ferroptosis is featured by irresolvable lipid peroxidation, which is mechanistically triggered by ferrous iron (Fe 2+ )-mediated Fenton reaction

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