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The BW loss in the MAD cohorts was maintained up to 150 days post-final dose

Similarly, severe heart failure or pulmonary edema represents a contraindication or strong precaution, as large amounts of glycine solution may expand intravascular volume and precipitate or worsen congestive heart failure or pulmonary congestion

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In a mixed meal tolerance test, the meal consists of 55% carbohydrate, 30% fat, and 15% protein