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Pediatric Reports

Since the liver is the major site of IGF-1 production, when steatosis develops lowering insulin sensitivity, the severity of steatosis at different stages of insulin resistance and metabolic syndrome seems to be correlated with worsened circulating IGF-1 levels [234]

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We studied participants with type 2 diabetes who were already using a stable dose of metformin in order to optimise the translational relevance of our findings

This article has outlined what retatrutide is being studied for, how it works at a physiological level, what is currently known about tolerance and side effects, and why its status differs from approved medications already in clinical use