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DNA demethylating drugs are thought to de-repress epigenetically silenced tumour suppressor genes as well as demethylate endogenous retroviruses (ERVs), triggering an antiviral immune response and cancer cell death (Chiappinelli et al , 2015

X.BlekkenhorstL.A.-O.WoodA.A.-O.et al (2024)

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Unfortunately, many people develop B12 deficiencies due to factors like poor diet, digestive issues, or underlying health conditions

It is remarkable that Vssc mutations have expanded greatly over the last three decades (Table 1) but that the specific mutations that confer the resistance have yet to be identified