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doi: 10.1016/S0167-0115(03)00120-4 [DOI] [PMC free article] [PubMed] [Google Scholar] 20.Gault VA, Flatt PR, Harriott P, Mooney MH, Bailey CJ, OHarte FP

But the strength of a mechanistic argument does not override the need for careful clinical judgment, and both therapeutic approaches carry risk profiles that must be understood and managed individually

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Given the limitations of the in vitro model using one human adipocyte cell line, further studies are necessary to confirm the hypothesis that nutrients, by stimulating the secretion of GLP-1, may influence the expression of irisin and thus modulate the mitochondrial metabolism of adipocytes.

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