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doi: 10.1016/j.tins.2020.09.008

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If a patient becomes pregnant whilst taking one of these agents they should contact their doctor immediately for advice: Diarrhoea and vomiting could affect absorption of oral contraceptives which in turn may reduce effectiveness

A shift toward brown or yellow, or visible precipitation, indicates the copper-peptide complex has dissociated or degraded, the same underlying copper-catalysed oxidation chemistry covered in our article on copper peptides and vitamin C