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in FAERS, the reporting odds ratio for ischemic optic neuropathy was 11.12
Kidney Concerns at High Doses In the 2-year MS trial using 1,200 mg/day, a greater number of participants in the alpha-lipoic acid group experienced protein in the urine (proteinuria) and poor kidney function compared to placebo [19]
The PCR products were purified using magnetic beads (Axygen Biosciences, Union City, CA, USA), and the concentration of the amplicon library was estimated using a 2100 Bioanalyzer System (Agilent Technologies Inc., Waldbronn, Germany)
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Moreover, alterations in the gut microbiota as described in mice require careful analysis in human studies including the assessment of a possible growth advantage for pathogenic bacteria as part of a commensal microbiome or with respect to systemic effects and clinical relevance
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