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1,38,39 Hypersecretion of GH leads to elevated concentrations of circulating IGF1 in acromegalic patients, and these two hormones may have different metabolic features and target tissue responses

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Research data shows the dual-receptor approach generates a larger GH pulse amplitude than GHRH-only stimulation, making it a different research tool for studying secretagogue synergy rather than isolated GHRH signaling

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LCMS analysis of the PDHc is more complex, given the two lipoylated sites on the PDHc-E2 subunit, and we were only able to reproducibly detect lipoyl moieties on K259