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Theres limited scientific evidence directly linking semaglutide use to vitamin B12 deficiency or recommending routine vitamin B12 supplementation for people taking semaglutide
Summary Keywords glucagon like peptide-1, irritable bowel syndrome, pain, IBS, agonist Citation Mostafa MEA and Alrasheed T (2025) Improvement of irritable bowel syndrome with glucagon like peptide-1 receptor agonists: a systematic review and meta-analysis
This is a question Im asked increasingly, and the honest answer as of mid-2026 is: not yet in clinical form but the science just arrived and its more interesting than most people realize
In the OASIS 4 clinical trial, the Wegovy pill produced an average weight loss of 16.6% of body weight over 64 weeks
But it doesnt have to be overwhelming, GoodRx says
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