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Immediate metabolic changes: Semaglutide can lower fasting glucose and postprandial glucose, sometimes necessitating adjustment of antidiabetic drugs

It has been shown to counteract NSAID-induced ulcers, esophagitis, and inflammatory bowel conditions like colitis by promoting epithelial integrity, increasing mucosal blood flow, and regulating the gut-brain axis

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Lower NAD+ levels are also associated with repair enzymes like PARP1 and sirtuins becoming less effective, allowing DNA damage and cellular stress to accumulate[1]