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In adipocytes, NNMT inhibition elevates NAD and SAM and suppresses de novo lipogenesis in a concentration-dependent manner, consistent with on-target activity [13]

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Additionally, these agonists have been shown to suppress oxidative stress and inflammation, which are known contributors to cognitive decline

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Gasiorek A et al

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doi: 10.1016/j.chom.2015.10.007 61 BronPAKleerebezemMBrummerRJCaniPDMercenierAMacDonaldTTet al

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