Birnbaum for continued support of the oral GLP-1R agonist program
In the Phase 2 trial, researchers looked at subjects with MASLD and found that the highest dose of retatrutide led to an 80% or greater reduction in liver fat content in a majority of participants
doi: 10.1097/WCO.0000000000000094
In contrast, Beta-1 receptors are mainly distributed in the heart, and can increase myocardial contractility, self-regulation, and conduction function
Since then, others have been made, including: Liraglutide (Victoza for diabetes, Saxenda for weight loss) Dulaglutide (Trulicity), Lixisenatide (Adlyxin) Semaglutide (Ozempic, Wegovy, and Rybelsus, which is a tablet) Tirzepatide (Mounjaro and Zepbound) works on two gut hormones, not just GLP1