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Many strategies to manage T2DM result in energy restriction and subsequent weight loss, and this can lead to significant declines in muscle mass in the absence of resistance exercise, which is also a first-line treatment for sarcopenia

Notably, CT-388's weight loss curve had not plateaued at 48 weeks, suggesting the final treatment effect could be even higher at 72 weeks in the Phase III program

What to do instead Our experts agree that the best course of action is to talk to your doctor or a registered dietitian before trying a GLP-1 supplement

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Plant Signal Behav 9(12):e977746