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Astrocytoma cells incubated with TNF and IFN and subsequently treated with setmelanotide exhibited reduced expression of chemokine CC motif ligand 2 (CCL2) and C-X-C motif chemokine 10 (CXCL10), while IL-6 and IL-11 mRNA levels were increased

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Among the tested doses, uridine at 10 mg/mL significantly improved the first polar body (PB1) extrusion rate in aged oocytes without observable toxicity, and was therefore selected as the optimal dose for subsequent experiments