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The researchers used three different measurements of antioxidant activity from blood samples: levels of glutathione S-transferase (GST), malondialdehyde (MDA) and trolox equivalent antioxidant capacity (TEAC)

Typical b12 deficiency symptoms include persistent fatigue, breathlessness, glossitis and pallor

Shore SE, Roberts LE, Langguth B

Decreased NAD + levels can contribute to sirtuin mediated deacetylase-dependent alterations in both mitochondrial electron transport activity (resulting in increased production of reactive oxygen species, ROS) as well as to increased nuclear DNA damage leading to the activation poly-ADP-ribose polymerases (PARP)

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