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Addition of the four metabolites (phosphocholine, phosphoethanolamine, cystathionine, and 2-hydroxybutyrate/2-hydroxyisobutyrate) significantly improved model fit (AIC: 39.3 vs 34.1

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MMA rises when B12 is functionally lacking inside the cells and is the more specific of the metabolic markers

METALLATION OF NON-HEME IRON ENZYMES In addition to ferritin, PCBPs exhibit iron chaperone activity toward other cytosolic iron enzymes

Similar results were seen in an additional study from this group that identified a modest increase in urinary MEHP in Taiwanese patients with either endometriosis or adenomyosis (Huang et al., 2014)