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This is because they are needed to support fetal development

Male SpragueDawley (SD) rats weighing 200 20 g were obtained from the Animal Experiment Center of the Fourth Military Medical University (Xian, China) and housed in a specific pathogen-free animal facility

What if I accidentally inject the water directly onto the powder

Yeah I wouldn't be surprised if it's some law or licensing issue that means that notice has to be put on the packet and in the instructions