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Liver energy metabolism reprogramming: GLP-1RA reduces hepatic glucose output by decreasing hepatic FFA uptake and the expression of key gluconeogenesis enzymes such as PEPCK and G6Pase, while promoting liver sensitivity to insulin, transforming the liver from an "energy output organ" to an "energy storage organ"

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For example, consider options like grilled chicken with quinoa and avocado, Greek yogurt topped with berries and nuts, or salmon paired with roasted vegetables and olive oil

If hyperglycemia persists, progression to a full basal-bolus regimen or premixed insulin schedule may then be warranted

The nausea-reducing mechanism of B12 conjugation is supported by preclinical research