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Gibson R, Krug L, Ramsey DL, Safaei A, Aspley S

[7] [14] Some anticonvulsants increase folate requirements, and specialist advice is recommended, especially when planning pregnancy

However, unexpectedly, K87pAcF showed the lowest stability among all the variants with the Tm value of 44.4 C, although it was predicted to be more stable than the wild type

Gene- and proteostasis-based strategies for monogenic disorders For diseases driven by single-transporter defects, gene-based therapies and pharmacological chaperones that restore proper trafficking, stability or function of mutant zinc transporters represent plausible longer-term strategies