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The thus validated model can also infer non-measured mechanistic variables such as -cell mass and liver insulin resistance, which is useful since it allows us to follow and understand what the model believes happens in the chips

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It binds to the glucagon receptor (GCGR) in hepatocytes, thereby enhancing glycogenolysis and gluconeogenesis, which promotes hepatic glucose production 4

The question then becomes maintenance, which involves how long to stay on semaglutide and what happens when you stop