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TNF- can induce the proliferation of fibroblast-like synoviocytes (FLS) and synovial cells by activating nuclear factor kappa-B (NF-B) and extracellular regulated protein kinases (Erk)-1/2-E26 transformation-specific (ETS)-1 signaling pathway, respectively (70, 71), resulting in the secretion of a variety of inflammatory mediators like IL-6, matrix metalloproteinases (MMP)-1, and MMP-3 to increase inflammation (72)

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FAA and KRB is the guarantors of this work, has full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analyses

In contrast, Glutathione Oxidized resin serves similar purposes but is often chosen for specific applications requiring different binding properties or conditions