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Moreover, as mentioned, beta-amyloid has other functions than just helping to fight off infection, and in small amounts both beta-amyloid 40 and beta-amyloid 42 promote neuronal survival ( APOE variants and amyloids, then, depends on circumstances like diet and pathogen exposure

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To chemically induce ERK5 degradation, CHAMP compounds were synthesized by covalently coupling HSP90- and ERK5-binding moieties using a short linker (HLE)