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Although SF3B1 IDR lacks an RNA-binding domain, another study indicated that P-SF3B1 can associate with RNA, suggesting that in cells even a negatively charged phosphorylated form of the protein can contribute to the interaction with negatively charged RNA 29

However, while they are recognized for their skin-lightening and brightening effects, the outcomes can vary and are not always predictable

Ghrelin strongly stimulates appetite (hence its role as the hunger hormone) and elevates cortisol and prolactin

A more accurate way to understand its role is that, by supporting hydration and helping to refine the appearance of skin texture, it may make pores look less prominent

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