10.3389/fonc.2021.759346 149 MaL.ZhangX.YuK.XuX.ChenT.ShiY.et al (2021)
CD31, Platelet Endothelial Cell Adhesion Molecule-1
Introduction -thalassemia is the most common inherited disease, characterized by decreased or absent -globin chain synthesis and hemoglobin A production ( The incidence of myocardial iron overload in transfusion-dependent -thalassemia patients has increased from 11.4%15.1% in early studies to 26.1%36.7% in recent studies ( As iron loading progresses, the capacity of transferrin to bind and detoxify iron is eventually exceeded, leading to non-transferrin-bound iron in plasma, which promotes oxidative stress, mitochondrial dysfunction, and ferroptosis ( Mechanisms of myocardial injury caused by iron overload Studies have shown that iron myocardial overload causes myocardial dysfunction
For intermediate precision of the method, the intraday and inter-day analysis was done, i.e., repeated the same concentrations six times a day at a gap of one hour each ( n = 6) and on 6 successive days, respectively
From there, we design a personalized plan that may include GLP-1s, nutrition support, and coaching
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