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For someone with metabolic dysfunction, MOTS-c might restore balance

The burden is particularly striking among high-risk populations: up to 70% of patients with type 2 diabetes mellitus (T2DM) are affected by NAFLD, and one in five adults with obesity and diabetes has NASH with clinically relevant fibrosis

doi: 10.3892/ijmm.2014.1792 201 WapenaarH.DekkerF

102 Effects of GLP-1RAs on Cardiovascular System Within the cardiovascular system, the GLP-1 receptor is expressed in both cardiac myocytes and endothelial cells, 103 indicating that GLP-1 receptor activation exerts both direct and indirect effects on cardiac and vascular functions

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