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In the context of the Melanotan-1 pathway, this suggests that peptide-driven activation of melanin production may still occur, but potentially at a lower efficiency compared to individuals with fully typical receptor function

Endogenous defense amplification Rather than transient ROS neutralization, these therapies enhance the cells innate antioxidant capacity by upregulating glutathione synthesis, antioxidant enzymes, and phase II detoxification systems

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