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It appears in plasma, saliva, and urine, and in younger years it is present at meaningfully higher levels

Pernicious anemia is an absorption failure caused by loss of intrinsic factor, usually autoimmune

The medication has undergone extensive clinical evaluation through the SUSTAIN trials for diabetes and STEP trials for weight management, establishing both efficacy and safety across diverse patient populations

A 2025 review by Araj and colleagues in the International Journal of Molecular Sciences described its geroprotective, antioxidant, and neuroprotective effects, while calling for more validation