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Current Opinion in Neurobiology, 4(5), 696-702.

Retatrutide is an investigational once-weekly injectable triple agonist that simultaneously activates GLP-1, GIP, and glucagon receptors, targeting appetite, glucose metabolism, and energy expenditure through a single agent

Clinical trial data from the SURMOUNT-1 study showed that up to 29% of participants on tirzepatide for weight loss experienced nausea, primarily during dose escalation phases

Jun 2014;10(6):839-857