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The STEP 5 trial demonstrated sustained weight loss over 104 weeks of continuous treatment

For type 2 diabetes, the FDA-approved maintenance doses of Ozempic range from 0.5 mg to 2.0 mg weekly, while the weight management indication (Wegovy) follows a specific titration schedule (0.250.51.01.72.4 mg at approximately 4-week intervals), with a maximum dose of 2.4 mg weekly

Participants experienced reductions in HbA1c, fasting glucose, triglycerides, and waist circumference, all of which are linked to lower cardiometabolic risk

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More recently, an in vivo/in vitro study using a mouse model of focal cerebral cortical ischemia revealed that the neuroprotective effects of liraglutide (i.e., reduced brain infarct volume, improved neurological recovery, and anti-neuroinflammatory effects) may be achieved through the inhibition of pyroptosis, which is special form of apoptosis associated with inflammation and mediated by inflammasome and caspase-1 activation [94]