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By medical definition, an agonist is a manufactured substance that attaches to a cell receptor and causes the same action as the naturally occurring substance. Named after the GLP-1 hormone or glucagon-like-peptide-1, the agonist medications work by mimicking the blood-lowering capacity of this hormone

Toxicol Sci 132:3242 Nakamichi N, Nakayama K, Ishimoto T, Masuo Y, Wakayama T, Sekiguchi H, Sutoh K, Usumi K, Iseki S, Kato Y (2016) Food-derived hydrophilic antioxidant ergothioneine is distributed to the brain and exerts antidepressant effect in mice

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We also look into how these choices are backed by science and where the evidence gap exists