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Not at the timepoints measured so far

For patients with diabetes, persistent sugar cravings accompanied by elevated blood glucose readings may indicate inadequate glycemic control requiring treatment intensification

Subsequent evaluations of the SUSTAIN and PIONEER trials have reaffirmed semaglutide's efficacy in diminishing both relative and absolute risks for significant adverse cardiovascular events in comparison to control therapies (Husain et al

So when it comes to transdermal preps, which are still systemic, so theyre being absorbed like those orals, um, but they are associated with a lower clot risk than oral estrogens, since the transdermal preps avoid that absorption in the stomach and the metabolism in the liver