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NeurolClin 2001;19:829

Systemic inflammation Conditions like endometriosis and PCOS/PMOS are associated with elevated inflammatory markers in follicular fluid, which directly affect the quality of the oocyte microenvironment

Therefore, SHANK3 mutations lead to various symptoms, including behavioral symptoms of ASD

Methylfolate helps power the methylation cycle, which regulates: Homocysteine metabolism Neurotransmitter production (serotonin, dopamine, norepinephrine) Hormone regulation Detoxification and antioxidant production DNA synthesis and repair When the MTHFR gene has a variant (like C677T or A1298C), the enzyme works less efficiently