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Leptin modulates the intrinsic excitability of AgRP/NPY neurons in the arcuate nucleus of the hypothalamus

It activates both GIP and GLP-1 receptors, producing the dual-agonist effects that differentiate it from semaglutide and other GLP-1-only medications

Nausea, mild discomfort, and bathroom changes are common

Physiol Behav 2010;99:3339 [DOI] [PMC free article] [PubMed] [Google Scholar] 11

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