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To accommodate the anticipated heterogeneity due to variations in population characteristics and study durations, random effects analysis models were employed

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The crude product was purified by a silica gel column chromatography using hexane and dichloromethane mixture (10:1 v/v) as eluent and obtained as yellow powder in 74% yield

doi: 10.1111/jgh.17037 88 YangSDuanZZhangSFanCZhuCFuRet al

The key takeaway is that dose increases typically bring temporary worsening, and the body generally adapts over time