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Individual response varies dramatically regardless of calculation method

[4] While occasional mild leg cramps may not require immediate medical attention, certain features warrant prompt evaluation by your healthcare provider to rule out more serious underlying conditions or complications

Cureus 14(10):e30812 Hogan AE, Gaoatswe G, Lynch L, Corrigan MA, Woods C, OConnell J et al (2014) Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus