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Therefore, when combined with high doses of ACEI and DPP-4i, substance P may lead to sympathetic activation rather than vasodilation

Oxidative stress is associated with induction of neurosteroid biosynthesis in the human brain (284), and TSPO ligands ( N , N -dialkyl-2-phenylindol-3-ylglyoxylamides) that also show anxiolytic activity promote a reduction in oxidative stress and pro-inflammatory enzymes in glial cells via promotion of neurosteroid synthesis (133)

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