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In this review, examples will be discussed how experimental conditions (dose, solvent, etc.), the experimental system (species, strain, and substrain in vivo, cell type, and in vitro conditions), and also adaptive responses and off-target effects of genetic manipulations and chemical interventions, can impact the mechanisms of cell death

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However, common use of the term in different experimental contexts can be confusing because the mechanisms regulating MOR function during short-term agonist exposure may or may not differ from mechanisms initiated during or following long-term agonist exposure