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Understanding how NRF2 coordinates different metabolic pathways to support cellular detoxification opens new avenues for therapeutic intervention

The mobile phase was composed of solvent A (10 mM ammonium acetate and 0.2% formic acid in water) and solvent B (10 mM ammonium acetate and 0.2% formic acid in 90% ACN)

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11 The JVS phenotype is inherited in an autosomal recessive manner and is characterized by growth retardation, fatty liver, hypoglycemia, hyperammonemia, and cardiac hypertrophy

The antagonism is explained by the fact that arginine and lysine are basic amino acids competing for renal tubular reabsorption