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Its research relevance is upstream: it stimulates the GHRH receptor, leading to GH release and downstream endocrine effects

We knock out Gipr in either the area postrema (AP) or hypothalamus of mice (Gipr AP-KO and Gipr hypo-KO , respectively) and compare body weight and food intake responses to GIPR agonists and antagonists, alone and in combination with the GLP-1R agonist liraglutide

Biotin, produced by intestinal bacteria, as well as that found in the diet, is bound to lysine residues in protein forming a complex that is called biocytin

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