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ASC/overlap can be differentiated from typical AIH by a lesser female predisposition, high serum alkaline phosphatase to aspartate aminotransferase (AST) ratio, presence of peri-nuclear anti-neutrophil cytoplasmic antibodies (p-ANCA), stronger association with inflammatory bowel disease (IBD), and a worse prognosis than typical AIH

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The utilization of N-acetyl cysteine (NAC) and the PI3K inhibitor (Ly294002) successfully inhibits the upregulation of AKR1C3 protein induced by cadmium

In spite of data from cell studies, the quantitative importance of the GST contribution in living organisms is not known

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