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Three DNA methyltransferase enzymes catalyze DNA methylation: Dnmt1, Dnmt3a, and Dnmt3b, which catalyze the transfer of a methyl group of S-adenosylmethionine (SAM) to the fifth carbon position of cytosine 26

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Valgus stress refers to the force that causes the knee to bend inward, creating a knock-knee alignment, while axial loading involves forces applied along the length of the leg

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