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Patients who have a lower cardiovascular risk should consider SGLT-2 inhibitors or GLP-1 agonists based on other established benefits such as weight control (moderate net weight loss for GLP-1 agonists and small weight loss for SGLT-2 inhibitors) against risks of genital infections (SGLT-2 inhibitors) or gastrointestinal disturbances (GLP-1 agonists)

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Routine supplementation with folic acid (the synthetic form of folate) is universally recommended