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Mannose polysaccharide, derived from mangosteen, serves as an oxygen-heterocyclic ketone that can antagonize the accumulation of reactive oxygen species induced by glutamate by activating the AMPK/SIRT1/peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC 1) pathway (Zhu et al., 2019)

Pozzilli et al., 2017

Patton L, Reverdito V, Bellucci A, Bortolon M, Macrelli A, Ricolfi L

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In addition, an increase in skin surface pH due to reduced levels of natural moisturizing factor, as occurs in FLG-deficient epidermis, could facilitate bacterial colonization and inflammation