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The double-blind STRIDE trial, conducted at 112 outpatient clinics in North America, Asia and Europe from October 2020 to July 2024, randomized 792 participants (median age 68 years, 25% women, 68% White) with T2D and PAD with intermittent claudication (Fontaine stage IIa) as well as an ankle-brachial index of 0.90 (mean 0.75) or toe-brachial index 0.70 (mean 0.48) to either once-weekly doses of subcutaneous semaglutide (n=396) or placebo (n=396) for 52 weeks

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Research published in the journal Diabetes, Obesity and Metabolism documented significant decreases in serum B12 levels in patients taking once-weekly semaglutide, alongside drops in zinc and albumin

Once opened, it can be kept at room temperature (1530C) for up to 4 weeks